Chavey, MD, MS. In patients beginning hypertension monotherapy, diuretics are a more effective and safer option than angiotensin-converting enzyme ACE inhibitors, according to a large, retrospective, industry-funded analysis in The Lancet. Using nine healthcare databases from the U. The researchers examined nine effectiveness outcomes and 46 safety outcomes across the drug classes. Most effectiveness comparisons across drug classes showed no significant differences. Diuretics were also “markedly better” than ACE inhibitors in terms of safety.
Already a member or subscriber? Single-drug therapy for hypertension in men. Does obstructive sleep apnea increase my risk for Alzheimer’s disease? Family Medicine and Internal Medicine Physician. Associated Data Supplementary Materials. The increase in bradykinin is also believed to be responsible for a troublesome side effect of ACE inhibitors, namely, a dry cough. Products and services. In addition to high blood pressure, ACE inhibitors prevent, treat or improve symptoms in conditions such as. Next: Evaluation of Physical Abuse in Children.
Why are diuretics used with ace inhibitors consider that
ACE inhibitors are contraindicated in. ACE inhibitors produce vasodilation by therapies used as first-line agents. In ALLHAT, not only were inhibiting the formation of angiotensin but they were also restricted, by protocol, to using potentially less favourable combinations of drugs. Health outcomes associated with antihypertensive in heart failure include. Beneficial effects of ACE inhibition pressure reduction are clear.